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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Opioids vs no opioids

Supplementary analgesic option offered (primary outcome 2) · participants with acute pancreatitis pain

Opioids may leads to lower supplementary analgesic option offered (primary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Pancreatitis complications (secondary outcome 1) · participants with acute pancreatitis pain

Opioids showed no clear difference in pancreatitis complications (secondary outcome 1) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Adverse drug events · participants with acute pancreatitis pain

Opioids showed no clear difference in any drug‐related adverse event (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Nausea and vomiting · participants with acute pancreatitis pain

Opioids showed no clear difference in nausea and vomiting (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Sedation and somnolence (secondary outcome 2) · participants with acute pancreatitis pain

Opioids showed no clear difference in sedation and somnolence (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids vs no opioids

Death from any cause (secondary outcome 3) · participants with acute pancreatitis pain

It is very uncertain whether opioids changes death from any cause (secondary outcome 3) compared with no opioids (very low certainty).

1 finding from 1 review