Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 12 findings · 1 reviews

No studies found 1 · 8.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 25%High 8 · 66.7%

Omega‐3 vs placebo

Any adverse event (combined: diarrhoea, urinary tract infection, falls, dizziness, agitations) · Apathy in people with mild‐to‐moderate Alzheimer's disease

Omega‐3 PUFA supplements showed no clear difference in any adverse event (combined: diarrhoea, urinary tract infection,… compared with placebo (moderate certainty).

1 finding from 1 review

Omega‐3 vs placebo

Serious adverse events "Defined as events that result in death, hospitalization, prolongation of hospitalization, or are life threatening (based on the judgment of the study physician)" (Quinn 2010) · Apathy in people with mild‐to‐moderate Alzheimer's disease

Omega‐3 PUFA supplements showed no clear difference in serious adverse events "Defined as events that result in death,… compared with placebo (high certainty).

1 finding from 1 review