Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 1 · 25%High 1 · 25%

Fast‐acting nicotine replacement therapy vs nicotine patch

Smoking cessation · people who smoke

Fast‐acting nicotine replacement therapy showed no clear difference in smoking cessation compared with nicotine patch (high certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.9 [0.77, 1.05]
8 studies · 3319 participants
High

Preloading nicotine replacement therapy (NRT) vs standard‐use NRT

Smoking cessation · people who smoke

Preloading nicotine replacement therapy (NRT) probably leads to higher smoking cessation compared with standard‐use NRT (moderate certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.25 [1.08, 1.44]
9 studies · 4395 participants
Moderate

Nicotine replacement therapy vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
RR 1.37 [1.08, 1.74]
9 studies · 2336 participants
Low

Bupropion plus nicotine replacement therapy (NRT) vs NRT

Smoking cessation · people who smoke

Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).

1 finding from 1 review

Antidepressants for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.17 [0.95, 1.44]
15 studies · 4117 participants
Low