Nicotine EC probably leads to higher smoking cessation at 6‐12 months compared with non‐nicotine EC (moderate certainty).
Nicotine EC showed no clear difference in adverse events at 1 week to 6 months Assessed via self‐report compared with non‐nicotine EC (moderate certainty).
Nicotine EC showed no clear difference in serious adverse events at 1 week to 1 year Assessed via self‐report… compared with non‐nicotine EC (low certainty).
Nicotine EC leads to higher smoking cessation at 6 months to 1 year compared with NRT (high certainty).
Nicotine EC showed no clear difference in adverse events at 4 weeks to 6‐9 months Assessed by self‐report compared with NRT (moderate certainty).
Nicotine EC showed no clear difference in serious adverse events at 4 weeks to 1 year Assessed via self‐report… compared with NRT (low certainty).
Nicotine EC may leads to higher smoking cessation at 6 to 12 months Assessed using biochemical… compared with behavioural support only/no support (low certainty).
Nicotine EC may leads to higher adverse events at 12 weeks to 6 months Assessed via self‐report compared with behavioural support only/no support (low certainty).
It is very uncertain whether nicotine EC changes serious adverse events at 4 weeks to 8 months Assessed via… compared with behavioural support only/no support (very low certainty).
Fast‐acting nicotine replacement therapy showed no clear difference in smoking cessation compared with nicotine patch (high certainty).
It is very uncertain whether fast‐acting nicotine replacement therapy changes treatment withdrawals compared with nicotine patch (very low certainty).
Preloading nicotine replacement therapy (NRT) probably leads to higher smoking cessation compared with standard‐use NRT (moderate certainty).
Preloading nicotine replacement therapy (NRT) showed no clear difference in overall serious adverse events compared with standard‐use NRT (low certainty).
It is very uncertain whether preloading nicotine replacement therapy (NRT) changes treatment withdrawals compared with standard‐use NRT (very low certainty).
Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in mean birthweight (g) compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in miscarriage and spontaneous abortion compared with control (low certainty).
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).