Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 1 · 16.7%Low 3 · 50%Moderate 0 · 0%High 0 · 0%

HFNC vs low flow nasal cannula (LFNC)

Death · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

1 finding from 1 review

High flow nasal cannula for respiratory support in term infants 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 95 participants
GRADE not reported

HFNC vs continuous positive airway pressure (CPAP)

Mortality before hospital discharge · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.78 [0.44, 1.39]
9 studies · 2009 participants
Low

HFNC vs nasal intermittent positive pressure ventilation

Mortality before hospital discharge · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) compared with nasal intermittent positive pressure ventilation (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.78 [0.36, 1.69]
3 studies · 254 participants
Low

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 1.09 [0.74, 1.6]
7 studies · 1830 participants
Low

HFNC vs nasal intermittent positive pressure ventilation

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.64 [0.3, 1.37]
2 studies · 182 participants
Very low

HFNC vs continuous positive airway pressure (CPAP)

Death · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

1 finding from 1 review

High flow nasal cannula for respiratory support in term infants 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 439 participants
GRADE not reported