What do systematic reviews say?

Topical NSAIDs vs topical placebo

• Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  42 studies · 6125 participants
  High

Topical NSAIDs vs topical placebo

• Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  38 studies · 5372 participants
  High

Topical NSAIDs vs topical placebo

• Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  42 studies · 5790 participants
  High

NSAIDs vs placebo

NSAIDs may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.28 [0.11, 0.7]
  1 study · 146 participants
  Low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs placebo

It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.76 [0.44, 7.1]
  1 study · 146 participants
  Very low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes hours compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.83 [0.59, 1.18]
  2 studies · 39 participants
  Very low

NSAIDs vs paracetamol

NSAIDs showed no clear difference in to 72 hours compared with paracetamol (low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.91 [0.54, 1.54]
  3 studies · 183 participants
  Low

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes to 7 days compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.74 [0.17, 3.23]
  2 studies · 38 participants
  Very low

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.71 [0.43, 6.9]
  3 studies · 281 participants
  Very low

NSAIDs vs paracetamol

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes reconsultations compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.13 [0.92, 1.4]
  1 study · 53 participants
  Very low

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes delayed antibiotic prescriptions compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.32 [0.74, 2.35]
  1 study · 53 participants
  Very low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs placebo

NSAIDs may leads to higher pain: ≥ 50% improvement in pain (spontaneous pain at 24 hours) compared with placebo (low certainty).

• Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  RR 2.75 [1.13, 6.72]
  Studies not reported
  Low

NSAIDs vs glucocorticoids

• Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate