Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 99 findings · 12 reviews

No studies found 23 · 23.2%GRADE not reported 18 · 18.2%Very low 27 · 27.3%Low 24 · 24.2%Moderate 5 · 5.1%High 2 · 2%

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3, Clinical resolution (not completely resolved) at 3 months: '1 study evaluated systemic treatment and 1 evaluated topical treatment. Neither found benefit for NSAIDs.' No GRADE. Effects text: celecoxib…
    2 studies
    GRADE not reported

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3 (NSAIDs vs placebo), Cancer development: SoF cell 'Not measured'. Effects text: cancer development was among outcomes in Papadimitrakopoulou 2008 (celecoxib) but did not occur in either arm, probably because of…
    1 study
    GRADE not reported

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3, Safety of the intervention over 3 months: systemic celecoxib (1 study) - 32 intervention participants reported 56 adverse effects, 20 placebo participants reported 20; 4 grade 3 events; 2 discontinued. Ketorolac…
    2 studies
    GRADE not reported

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia

The review found no eligible studies for this question.

1 finding from 1 review

Oral NSAIDs vs glucocorticoid injection

Treatment success Fair, good or excellent effectiveness · Adults with lateral elbow pain

It is very uncertain whether oral NSAIDs changes treatment success Fair, good or excellent effectiveness compared with glucocorticoid injection (very low certainty).

1 finding from 1 review