What do systematic reviews say?

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes to 7 days compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.74 [0.17, 3.23]
  2 studies · 38 participants
  Very low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs combination (paracetamol and opioid) analgesic

It is very uncertain whether NSAID changes little or no pain at 1 to 3 days compared with combination (paracetamol and opioid) analgesic (very low certainty).

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  RR 1.49 [0.65, 3.4]
  2 studies · 149 participants
  Very low

NSAIDs vs paracetamol

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1232 participants
  High