Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 5 · 62.5%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
No studies in this comparison reported any adverse events. SoF cell: 'Not reported'.
0 studies
No studies found

NSAIDs vs paracetamol

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.71 [0.43, 6.9]
3 studies · 281 participants
Very low

NSAIDs vs placebo

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.76 [0.44, 7.1]
1 study · 146 participants
Very low

NSAIDs vs combination (paracetamol and opioid) analgesic

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.52 [0.09, 2.84]
3 studies · 141 participants
Very low

NSAIDs vs paracetamol

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in neurological adverse events compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.85 [0.62, 1.17]
9 studies · 1679 participants
Low

NSAIDs vs combination (paracetamol and opioid) analgesic

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes gastrointestinal adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.21 [0.03, 1.74]
3 studies · 141 participants
Very low

NSAIDs vs paracetamol

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 1.34 [0.97, 1.86]
10 studies · 1504 participants
Low

NSAID (systemic) vs paracetamol

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
In one study, one participant (<1%) in the paracetamol group experienced drug hypersensitivity (a 'red, blotchy and itchy rash') that resolved without treatment within 1 week (Bradley 2007 / McAlinden 2005); 1 RCT;…
1 study
Very low