Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 93 findings · 9 reviews

No studies found 30 · 32.3%GRADE not reported 6 · 6.5%Very low 22 · 23.7%Low 29 · 31.2%Moderate 6 · 6.5%High 0 · 0%

Morphine vs buprenorphine

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

1 finding from 1 review

Morphine vs fentanyl

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Morphine vs metamizole

Improvements in pain intensity as defined by the trialist (primary outcome) · participants with acute pancreatitis pain

Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).

1 finding from 1 review

Morphine vs Tricyclic antidepressant (nortriptyline)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine led to lower average pain scores (0-100 VAS) compared with tricyclic antidepressant (nortriptyline); GRADE not reported.

1 finding from 1 review