Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Monotherapy vs combination therapy compared

All‐cause mortality—same beta lactam Survival · patients with sepsis

Monotherapy showed no clear difference in all‐cause mortality—same beta lactam Survival compared with combination therapy compared (low certainty).

1 finding from 1 review

Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis 2014 · Cochrane Headline outcomes only
RR 0.97 [0.73, 1.3]
13 studies · 1431 participants
Low

Monotherapy vs combination therapy compared

All‐cause mortality—different beta lactam · patients with sepsis

Monotherapy showed no clear difference in all‐cause mortality—different beta lactam compared with combination therapy compared (low certainty).

1 finding from 1 review

Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis 2014 · Cochrane Headline outcomes only
RR 0.85 [0.71, 1.01]
31 studies · 4146 participants
Low

Monotherapy vs combination therapy compared

Clinical failure—same beta lactam Antibiotic modifications · patients with sepsis

It is very uncertain whether monotherapy changes clinical failure—same beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).

1 finding from 1 review

Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis 2014 · Cochrane Headline outcomes only
RR 1.11 [0.95, 1.29]
20 studies · 1870 participants
Very low

Monotherapy vs combination therapy compared

Clinical failure—different beta lactam Antibiotic modifications · patients with sepsis

It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).

1 finding from 1 review

Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis 2014 · Cochrane Headline outcomes only
RR 0.75 [0.67, 0.84]
46 studies · 4933 participants
Very low