Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

139 questions · 143 findings · 11 reviews

No studies found 17 · 11.9%GRADE not reported 8 · 5.6%Very low 41 · 28.7%Low 56 · 39.2%Moderate 21 · 14.7%High 0 · 0%

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower women's dissatisfaction with the procedure compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Hysterectomy to control bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes hysterectomy to control bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Number of women with total blood loss 1000 mL or more after randomisation · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes number of women with total blood loss 1000 mL or more after… compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mean blood loss (mL) (trialist defined) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes blood transfusion (red cell or whole blood) compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Side effects of the intervention (e.g. trauma, necrosis) ‐ Severe shivering, diarrhoea, vomiting or high temperature · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…
1 finding from 1 review

Advance misoprostol distribution/provision to pregnant women for postpartum self‐administration vs usual care

Maternal transfer or referral to a health facility · women in the third stage of labour

It is very uncertain whether advance misoprostol distribution/provision to pregnant women for… changes maternal transfer or referral to a health facility compared with usual (or standard) care (very low certainty).

1 finding from 1 review