It is very uncertain whether misoprostol changes surgical evacuation compared with surgery (very low certainty).
Misoprostol probably leads to lower ease of dilatation: need for mechanical dilatation compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
Misoprostol may leads to higher ease of dilatation: need for mechanical dilatation compared with osmotic dilator before operative hysteroscopy (low certainty).
Misoprostol showed no clear difference in intraoperative complications compared with osmotic dilator before operative hysteroscopy (low certainty).
Misoprostol probably leads to lower intraoperative complications compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
Misoprostol probably leads to lower specific intraoperative complications ‐ Cervical laceration/tear compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
Misoprostol probably leads to lower specific intraoperative complications ‐ False track compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine perforation compared with placebo or no treatment before operative hysteroscopy (low certainty).
Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine bleeding compared with placebo or no treatment before operative hysteroscopy (low certainty).
Misoprostol probably leads to higher side effects compared with placebo or no treatment before operative hysteroscopy (moderate certainty).
Misoprostol may leads to lower ease of dilatation: need for mechanical dilatation compared with dinoprostone before operative hysteroscopy (low certainty).
Misoprostol may leads to lower intraoperative complications compared with dinoprostone before operative hysteroscopy (low certainty).
Misoprostol showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (moderate certainty).
Misoprostol showed no clear difference in need for blood transfusion Number of participants who received blood… compared with placebo to reduce blood loss during myomectomy (low certainty).
Misoprostol showed no clear difference in duration of surgery (min) Operative time compared with placebo to reduce blood loss during myomectomy (low certainty).
Oral misoprostol probably leads to higher failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).
Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.