Findings

What do systematic reviews say?

8 questions · 9 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 1 · 11.1%Very low 0 · 0%Low 6 · 66.7%Moderate 2 · 22.2%High 0 · 0%

Misoprostol vs surgery

Nausea · incomplete miscarriage

Misoprostol may leads to higher nausea compared with surgery (low certainty).

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
RR 2.5 [1.53, 4.09]
11 studies · 3015 participants
Low

Misoprostol vs expectant care

Nausea · incomplete miscarriage

1 finding from 1 review

Medical treatments for incomplete miscarriage 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Oral misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.14 [1.03, 1.26]
2 studies · 1380 participants
Low
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.21 [0.92, 1.61]
2 studies · 216 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Sublingual misoprostol showed no clear difference in nausea compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.11 [0.93, 1.33]
3 studies · 3543 participants
Moderate

Sublingual misoprostol vs vaginal misoprostol

Nausea · first trimester abortion

Sublingual misoprostol alone showed no clear difference in nausea compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.61 [0.78, 3.33]
4 studies · 2505 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher nausea compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 21.85 [1.31, 364.37]
1 study · 154 participants
Low

Vaginal misoprostol vs placebo

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in nausea compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.38 [0.43, 4.4]
2 studies · 88 participants
Low

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Nausea · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg showed no clear difference in nausea compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.99 [0.94, 1.05]
3 studies · 4424 participants
Moderate