Findings

What do systematic reviews say?

5 questions · 11 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 9 · 81.8%Very low 2 · 18.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.26 [-0.83, 0.31]
1 study · 22 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.12, 0.32]
3 studies · 84 participants
GRADE not reported

Metronidazole + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.11 [-2.84, 0.61]
2 studies · 47 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.59 [-0.95, -0.23]
4 studies · 94 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.10 [-0.37, 0.16]
4 studies · 108 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Probing pocket depth · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.20 [-0.35, -0.05]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.26, 0.06]
1 study · 46 participants
GRADE not reported

Metronidazole gel 25% (local antibiotic) vs Ultrasonic debridement

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Metronidazole gel 25% (local antibiotic) showed no clear difference in change in probing pocket depth compared with ultrasonic debridement; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
12 weeks
After 12 weeks there was no statistically significant difference in PPD changes.
1 study · 27 participants
GRADE not reported