Findings

What do systematic reviews say?

27 questions · 27 findings · 2 reviews

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No studies found 7 · 25.9%GRADE not reported 0 · 0%Very low 5 · 18.5%Low 10 · 37%Moderate 5 · 18.5%High 0 · 0%

Macrolides vs doxycycline

Serious adverse events · adults and adolescents with scrub typhus

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 242 participants
Very low

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
RR 2.71 [0.12, 63.84]
3 studies · 242 participants
Very low

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
RR 0.81 [0.32, 2.03]
2 studies · 150 participants
Very low

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
RR 1.05 [0.99, 1.1]
2 studies · 185 participants
Low

Macrolides vs doxycycline

Time to defervescence · adults and adolescents with scrub typhus

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 242 participants
Very low

Macrolides vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides probably leads to lower ≥ 1 exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.34 [0.22, 0.54]
3 studies · 341 participants
Moderate

Macrolides vs no intervention

All‐cause mortality · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 88 participants
Very low

Macrolides vs no intervention

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Moderate

Macrolides vs no intervention

Change in SGRQ total score · adults with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Moderate

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
IRR 0.5
1 study · 89 participants
Low

Macrolides vs placebo

Hospitalisation (any cause) · children with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all‐cause compared with placebo (low certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.28 [0.07, 1.11]
1 study · 89 participants
Low

Macrolides vs placebo

Serious adverse events · children with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.43 [0.17, 1.05]
1 study · 89 participants
Low

Macrolides vs placebo

All‐cause mortality · children with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Low

Macrolides vs placebo

Quality of life not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Exacerbations ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

Hospitalisation ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs placebo

Hospitalisation (any cause) · adults with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all cause compared with placebo (low certainty).

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.56 [0.19, 1.62]
2 studies · 151 participants
Low

Macrolides vs no intervention

Serious adverse events ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Macrolides vs no intervention

All‐cause mortality · children with bronchiectasis

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

Macrolides vs no intervention

Quality of life ‐ not reported · children with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found