Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV probably leads to lower non‐cessation of seizures compared with diazepam IV (moderate certainty).
1 finding from 1 review
Requirement for ventilatory support · patients with status epilepticus
Lorazepam IV showed no clear difference in requirement for ventilatory support compared with diazepam IV (low certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
1 finding from 1 review
Continuation of status requiring a different drug or general anaesthesia · patients with status epilepticus
Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).
1 finding from 1 review
Death · patients with status epilepticus
1 finding from 1 review
Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV showed no clear difference in non‐cessation of seizures compared with diazepam plus phenytoin IV (low certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
Lorazepam IV showed no clear difference in adverse effects compared with diazepam plus phenytoin IV (moderate certainty).
1 finding from 1 review
Deaths · patients with status epilepticus
1 finding from 1 review
Requirement for ventilatory support · patients with status epilepticus
1 finding from 1 review
Seizure freedom · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam showed no clear difference in seizure cessation compared with diazepam (low certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam probably leads to lower incidence of respiratory depression compared with diazepam (moderate certainty).
1 finding from 1 review
Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam showed no clear difference in additional drugs required to terminate the seizure: additional dose… compared with diazepam (low certainty).
1 finding from 1 review
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam showed no clear difference in seizure recurrence within 24 hours compared with diazepam (moderate certainty).
1 finding from 1 review
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam may leads to lower incidence of admissions to the ICU compared with diazepam (low certainty).
1 finding from 1 review
Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
1 finding from 1 review