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Evidence found and GRADE certainty

113 questions · 114 findings · 6 reviews

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No studies found 36 · 31.6%GRADE not reported 3 · 2.6%Very low 16 · 14%Low 28 · 24.6%Moderate 18 · 15.8%High 13 · 11.4%

Lithium as sole treatment vs placebo

Thyroid dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive lithium + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Response to treatment clinically relevant response as defined by the authors · schizophrenia

Adjunctive lithium + antipsychotics may leads to higher response to treatment clinically relevant response as defined by the… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).

1 finding from 1 review

Adjunctive lithium + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Clinically significant response on manic symptoms at least 50% Bech‐Rafaelsen improvement · schizophrenia

Adjunctive lithium + antipsychotics showed no clear difference in clinically significant response on manic symptoms at least 50%… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).

1 finding from 1 review

Adjunctive lithium + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia

Adjunctive lithium + antipsychotics showed no clear difference in clinically significant response on positive symptoms at least 50% MS… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).

1 finding from 1 review

Metal-free FDPs (lithium disilicate) vs Metal-ceramic FDPs

Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge failure compared with metal-ceramic FDPs (very low certainty).

2 findings from 1 review

Mood stabilisers vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether mood stabilisers, including antiepileptics and lithium changes repetition of SH by post‐intervention№ of participants: 167(1 RCT) compared with placebo (very low certainty).

1 finding from 1 review