Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 0 · 0%High 1 · 33.3%

Infection · Adults and children (haemodynamically stable) with potential need for RBC transfusion

Liberal showed no clear difference in infection compared with restrictive transfusion protocols (high certainty).

1 finding from 1 review

Transfusion thresholds for guiding red blood cell transfusion 2021 · Cochrane Headline outcomes only
RR 0.97 [0.88, 1.07]
25 studies · 17104 participants
High

Wound infection · Patients with hip fracture repair

Liberal showed no clear difference in wound infection (in hospital) compared with restrictive threshold transfusion (low certainty).

1 finding from 1 review

Red blood cell transfusion for people undergoing hip fracture surgery 2015 · Cochrane Headline outcomes only
RR 1.61 [0.77, 3.35]
3 studies · 2332 participants
Low

Respiratory infections (namely pneumonia) · Patients with hip fracture repair

Liberal showed no clear difference in respiratory infections (namely pneumonia) compared with restrictive threshold transfusion (low certainty).

1 finding from 1 review

Red blood cell transfusion for people undergoing hip fracture surgery 2015 · Cochrane Headline outcomes only
RR 1.35 [0.95, 1.92]
4 studies · 2416 participants
Low