50% or greater reduction in focal seizure frequency (responders) intention to treat– all doses · people with drug‐resistant focal epilepsy
Levetiracetam probably leads to higher 50% or greater reduction in focal seizure frequency (responders)… compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawal rates ‐ Any dose · people with drug‐resistant focal epilepsy
Levetiracetam showed no clear difference in treatment withdrawal– all doses compared with placebo (high certainty).
1 finding from 1 review
Somnolence · people with drug‐resistant focal epilepsy
Levetiracetam probably leads to higher adverse effects: 5 most common adverse effects (any age) – somnolence compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: headache · people with drug‐resistant focal epilepsy
Levetiracetam showed no clear difference in adverse effects: 5 most common adverse effects (any age) – headache compared with placebo (low certainty).
1 finding from 1 review
Adverse effects: 5 most common adverse effects (any age) – dizziness · people with drug‐resistant focal epilepsy
Levetiracetam showed no clear difference in adverse effects: 5 most common adverse effects (any age) – dizziness compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effect: fatigue · people with drug‐resistant focal epilepsy
Levetiracetam showed no clear difference in adverse effects: 5 most common adverse effects (any age) – fatigue… compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: 5 most common adverse effects (any age) – accidental injury · people with drug‐resistant focal epilepsy
Levetiracetam showed no clear difference in adverse effects: 5 most common adverse effects (any age) –… compared with placebo (low certainty).
1 finding from 1 review
Seizure freedom · patients with AD and epileptic seizures
It is very uncertain whether levetiracetam changes proportion with seizure freedom compared with lamotrigine (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · patients with AD and epileptic seizures
It is very uncertain whether levetiracetam changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).
1 finding from 1 review
Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in cognition · patients with AD and epileptic seizures
1 finding from 1 review
Change in neuropsychiatric symptoms · patients with AD and epileptic seizures
1 finding from 1 review
Improvement in quality of life · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion with adverse events · patients with AD and epileptic seizures
It is very uncertain whether levetiracetam changes proportion with adverse events compared with lamotrigine (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · patients with AD and epileptic seizures
It is very uncertain whether levetiracetam changes reduction in seizure frequency of 50% or more compared with lamotrigine (very low certainty).
1 finding from 1 review
Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in cognition · patients with AD and epileptic seizures
1 finding from 1 review
Change in neuropsychiatric symptoms · patients with AD and epileptic seizures
1 finding from 1 review
Improvement in quality of life · patients with AD and epileptic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure freedom · patients with AD and epileptic seizures
It is very uncertain whether levetiracetam changes proportion with seizure freedom compared with phenobarbital (very low certainty).
1 finding from 1 review