Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 2 · 28.6%GRADE not reported 1 · 14.3%Very low 1 · 14.3%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Frequency of crisis · sickle cell disease

L‐arginine showed no clear difference in frequency of crisis (monthly crisis) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
RR 0.71 [0.26, 1.95]
1 study · 50 participants
Low

Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain) · sickle cell disease

L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 125 participants
Low

QoL of participants living with SCD and their caregivers · sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse effects · sickle cell disease

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 125 participants
GRADE not reported

Frequency of hospitalization (number of days in hospital) · sickle cell disease

It is very uncertain whether L‐arginine changes frequency of hospitalization (number of days in hospital) compared with placebo (very low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 125 participants
Very low

Frequency of sickle cell‐related complications · sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Haemoglobin status · sickle cell disease

L‐arginine showed no clear difference in haemoglobin status (g/dL) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
MD 0.4
2 studies · 106 participants
Low