evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

23 questions · 23 findings · 3 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 1 · 4.3%GRADE not reported 4 · 17.4%Very low 9 · 39.1%Low 5 · 21.7%Moderate 4 · 17.4%High 0 · 0%

Ketorolac vs placebo

Use of rescue medication · children with acute postoperative pain

It is very uncertain whether ketorolac changes participants using rescue medication in the PACU compared with placebo (very low certainty).

1 finding from 1 review

Ketorolac vs placebo

Participants experiencing bleeding events · children with acute postoperative pain

It is very uncertain whether ketorolac changes participants experiencing bleeding events compared with placebo (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Participant‐reported pain relief of 50% or greater · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants with at least 50% pain relief over 4 hours compared with placebo (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Number of women requiring rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Number of participants reporting an adverse event · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants reporting any adverse event compared with another NSAID (moderate certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Number of participants experiencing any serious adverse events · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Relief of pain · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac may leads to higher number of participants with at least 50% pain relief over 6 hours compared with placebo (low certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Use of rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with placebo (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Number of participants reporting an adverse event · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants reporting any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Number of participants experiencing any serious adverse events · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants experiencing a serious adverse event compared with placebo (low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Participant‐reported pain relief of 50% or greater · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants with at least 50% pain relief over 4 hours compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Relief of pain · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants with at least 50% pain relief over 6 hours compared with another NSAID (moderate certainty).

1 finding from 1 review

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    3 months
    SoF 3, Clinical resolution (not completely resolved) at 3 months: '1 study evaluated systemic treatment and 1 evaluated topical treatment. Neither found benefit for NSAIDs.' No GRADE. Effects text: celecoxib…
    2 studies
    GRADE not reported