Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

536 questions · 579 findings · 94 reviews

No studies found 151 · 26.1%GRADE not reported 52 · 9%Very low 182 · 31.4%Low 120 · 20.7%Moderate 52 · 9%High 22 · 3.8%

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (6 to 9 months) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (6 to 9 months) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (12 months+) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (12 months+) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Adverse effects of the interventions · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

The review found no eligible studies for this question.

1 finding from 1 review

Provider‐ or system‐based interventions vs no intervention or another intervention

Posters in clinic displaying influenza vaccination rates to encourage doctors to compete plus postcards to participants compared to posters alone · people aged 60 years and older living in the community

Provider‐ or system‐based interventions showed no clear difference in posters in clinic displaying influenza vaccination rates to… compared with no intervention or another intervention (high certainty).

1 finding from 1 review

One-to-one dietary intervention aimed at preventing tooth erosion (e.g., reducing consumption of acidic/carbonated drinks) vs No dietary advice, or different dietary advice

Dental erosion / tooth wear (tooth wear indices) · Participants of any age receiving one-to-one dietary advice in a dental setting

The review found no eligible studies for this question.

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Bone mineral density · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher bone Mineral Density 1 compared with standard care (high certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of eyes in which SEI had developed within 21 days of… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants who discontinued medication and did not… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review