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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

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No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

Summary of findings table (subcomparison 2): second‐line… may leads to lower progression‐free survival compared with control intervention alone (low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy

It is very uncertain whether summary of findings table (subcomparison 2): second‐line… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Taking adherence · solid organ transplant recipients

Interventions for increasing immunosuppressant medication adherence showed no clear difference in taking adherence compared with standard care (low certainty).

1 finding from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Dosing adherence · solid organ transplant recipients

Interventions for increasing immunosuppressant medication adherence may leads to higher dosing adherence compared with standard care (low certainty).

1 finding from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Timing adherence · solid organ transplant recipients

Interventions for increasing immunosuppressant medication adherence showed no clear difference in timing adherence compared with standard care (low certainty).

1 finding from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Drug holidays · solid organ transplant recipients

Interventions for increasing immunosuppressant medication adherence showed no clear difference in drug holidays compared with standard care (low certainty).

1 finding from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Adherence · solid organ transplant recipients

It is very uncertain whether interventions for increasing immunosuppressant medication adherence changes self‐reported adherence (proportion) compared with standard care (very low certainty).

2 findings from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Proportion of immunosuppressant trough concentration levels at target · solid organ transplant recipients

It is very uncertain whether interventions for increasing immunosuppressant medication adherence changes proportion of immunosuppressant trough concentration levels at target compared with standard care (very low certainty).

1 finding from 1 review

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Pain associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Effects of practice‐based interprofessional collaboration (IPC) interventions on professional practice and healthcare outcomes vs alternative IPC intervention

Clinical process or efficiency outcomes · health and social care professionals involved in the delivery of health services and patient care
1 finding from 1 review

Effects of practice‐based interprofessional collaboration (IPC) interventions on professional practice and healthcare outcomes vs alternative IPC intervention

Patient health outcomes · health and social care professionals involved in the delivery of health services and patient care

The review found no eligible studies for this question.

1 finding from 1 review

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) vs placebo or active comparators (paracetamol, tranexamic acid)

Menstrual blood loss: mean loss

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in menstrual blood loss (alkaline hematin method) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.

2 findings from 1 review

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) vs placebo or active comparators (paracetamol, tranexamic acid)

Duration of bleeding (menstrual diary)

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in duration of bleeding (menstrual diary) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.

1 finding from 1 review