Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,486 questions · 2,727 findings · 268 reviews

No studies found 600 · 22%GRADE not reported 229 · 8.4%Very low 789 · 28.9%Low 707 · 25.9%Moderate 314 · 11.5%High 88 · 3.2%

Pregabalin vs placebo

Treatment‐related adverse effects · adults and children with sickle cell disease experiencing neuropathic pain

It is very uncertain whether summary of findings ‐ Pharmacological intervention (pregabalin) changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Total mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in total mortalityDeaths compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Cardiac mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation may leads to lower cardiac mortalityDeaths compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Non‐fatal MI · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in non‐fatal MI compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Revascularisation (CABG and PCI combined) · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in revascularisation (CABG and PCI combined) compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Skill acquisition Mean inhaler technique score (%), higher score indicates better technique. Scale from: 0 to 100. · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Health outcome (Number who had a medical complication of pelvic inflammatory disease) · patients taking prescribed and over‐the‐counter medications or their carers

Summary of findings: multimedia education and a co‐intervention showed no clear difference in health outcome (Number who had a medical complication of pelvic… compared with co‐intervention alone (low certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Medication side effects Mean adverse self‐medication behaviour score (lower scores indicate safer self‐medication behaviour). Scale from: 0 to 40. · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: olanzapine + supportive intervention changes prodromal symptoms: transition to psychosis Endpoint data, (events)… compared with placebo + supportive intervention (very low certainty).

1 finding from 1 review