Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,486 questions · 2,727 findings · 268 reviews

No studies found 600 · 22%GRADE not reported 229 · 8.4%Very low 789 · 28.9%Low 707 · 25.9%Moderate 314 · 11.5%High 88 · 3.2%

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants with adverse effects ‐ measured over 20… compared with placebo with PUVA therapy (very low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Breath holding · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

It is very uncertain whether adverse effects of pharmacological intervention changes breath holding compared with control (very low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Chest tightness · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

It is very uncertain whether adverse effects of pharmacological intervention changes chest tightness compared with control (very low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Cough · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Adverse effects of pharmacological intervention may leads to higher cough compared with control (low certainty).

1 finding from 1 review

Adverse effects of pharmacological intervention vs control

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · adults and children undergoing general anaesthesia including the muscle relaxant rocuronium bromide

Adverse effects of pharmacological intervention showed no clear difference in pain on injection compared with control (low certainty).

1 finding from 1 review

Lifestyle interventions vs placebo or usual care

Overall survival (24 months) · weight reduction in obesity to improve survival in women with endometrial cancer

It is very uncertain whether summary of findings table ‐ Lifestyle intervention changes overall survival (24 months) compared with usual care compared to placebo (very low certainty).

1 finding from 1 review

Lifestyle interventions vs placebo or usual care

Adverse events – musculoskeletal · weight reduction in obesity to improve survival in women with endometrial cancer

It is very uncertain whether summary of findings table ‐ Lifestyle intervention changes adverse events – musculoskeletal compared with usual care compared to placebo (very low certainty).

1 finding from 1 review

Lifestyle interventions vs placebo or usual care

Cardiovascular and metabolic event frequency (12 months) (Number of strokes, myocardial infarctions and hospitalisations for heart failure) · weight reduction in obesity to improve survival in women with endometrial cancer

Summary of findings table ‐ Lifestyle intervention showed no clear difference in cardiovascular and metabolic event frequency (6 months) compared with usual care compared to placebo (low certainty).

1 finding from 1 review

Water, sanitation, and hygiene (WASH) intervention vs no WASH intervention

Any STH prevalence · children and adults

Water, sanitation, and hygiene (WASH) intervention showed no clear difference in any STH prevalence compared with no WASH intervention (moderate certainty).

1 finding from 1 review