Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).
1 finding from 1 review
Patients with serious adverse health events (duration 12 to 52 weeks) · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in patients with serious adverse health events (duration 12 to 52 weeks) compared with daily ICS (low certainty).
1 finding from 1 review
Patients with at least 1 exacerbation requiring emergency department/acute care visit (duration 12 to 52 weeks) · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in patients with at least 1 exacerbation requiring emergency… compared with daily ICS (low certainty).
1 finding from 1 review
Change from baseline AM PEFR (%) (duration 44 to 52 weeks) · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in change from baseline AM PEFR (%) (duration 44 to 52 weeks) compared with daily ICS (moderate certainty).
1 finding from 1 review
Asthma control · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in proportion of asthma control days over the period (duration 44 to 52… compared with daily ICS (moderate certainty).
1 finding from 1 review
Change from baseline mean daily use of β2‐agonists (puffs/day) (duration 24 to 44 weeks) · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in change from baseline mean daily use of β2‐agonists (puffs/day)… compared with daily ICS (moderate certainty).
1 finding from 1 review
Change in height · Children and adults with persistent asthma.
Intermittent 'as needed' ICS probably leads to higher change in height (cm) (duration 44 to 52 weeks) compared with daily ICS (moderate certainty).
1 finding from 1 review
Leaving the study early · Children and adults with persistent asthma.
Intermittent 'as needed' ICS showed no clear difference in overall withdrawals (duration 12 to 52 weeks) compared with daily ICS (low certainty).
1 finding from 1 review