What do systematic reviews say?

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality at day 30 compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.88 [0.81, 1.1]
  5 studies · 2402 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality after 30 days post‐randomisation compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.8, 1.06]
  5 studies · 2759 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in patients free of RRT after discontinuing CRRT compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.91, 1.37]
  5 studies · 2402 participants
  Low
• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.98 [0.94, 1.01]
  3 studies · 988 participants
  Moderate

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive leads to higher adverse events: hypophosphataemia compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 1.21 [1.11, 1.31]
  1 study · 1441 participants
  High

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.69, 1.27]
  5 studies · 966 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients without sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.89 [0.69, 1.15]
  4 studies · 1216 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive leads to lower mortality: patients with AKI related to cardiac or general surgery compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.73 [0.61, 0.88]
  2 studies · 531 participants
  High

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with AKI not related to surgery compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.73, 1.2]
  3 studies · 1871 participants
  Low

More intensive vs less intensive insulin therapy

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  RR 1.12 [0.32, 3.94]
  4 studies · 301 participants
  Very low

More intensive vs less intensive insulin therapy

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  RR 0.63 [0.42, 0.93]
  2 studies · 153 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Very low

More intensive vs less intensive insulin therapy

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  RR 0.68 [0.29, 1.58]
  3 studies · 208 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 301 participants
  Very low

More intensive vs less intensive insulin therapy

• Glucose‐lowering agents for treating pre‐existing and new‐onset diabetes in kidney transplant recipients 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Very low