Recurrence · adults with basal cell carcinoma of the skin
Imiquimod cream probably leads to lower recurrence at 3 years compared with MAL‐PDT (moderate certainty).
2 findings from 1 review
Cosmesis · adults with basal cell carcinoma of the skin
Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).
1 finding from 1 review
Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin
Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).
1 finding from 1 review
Early treatment failure · adults with basal cell carcinoma of the skin
Imiquimod cream showed no clear difference in early treatment failure compared with MAL‐PDT (moderate certainty).
1 finding from 1 review
Primary outcome: Histological complete response ( available‐case analysis) No residual LM in staged excision 2 months post‐treatment · participants with melanoma in situ, including lentigo maligna
Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in primary outcome: Histological complete response (intention‐to‐treat)… compared with imiquimod 5% cream alone (low certainty).
2 findings from 1 review
Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna
Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).
1 finding from 1 review
Secondary outcome: Inflammatory response (number of lesions with grade 2 or 3) Grade 2 or 3 Inflammation² · participants with melanoma in situ, including lentigo maligna
Imiquimod 5% cream with tazarotene 0.1% gel may leads to higher secondary outcome: Inflammatory response (number of lesions with… compared with imiquimod 5% cream alone (low certainty).
1 finding from 1 review
Secondary outcome: Inflammatory response (overall Inflammation score) for all participants Mean grade of inflammation in each group² · participants with melanoma in situ, including lentigo maligna
1 finding from 1 review