What do systematic reviews say?

IVF vs expectant management

It is very uncertain whether IVF changes live birth per woman randomised compared with expectant management (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 22 [2.56, 189.37]
  1 study · 51 participants
  Very low

IVF vs unstimulated IUI

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with unstimulated IUI (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.72 [0.14, 21.25]
  1 study · 43 participants
  Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in live birth rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.19 [0.87, 1.61]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in clinical pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.17 [0.85, 1.59]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in multiple pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 0.82 [0.38, 1.77]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

It is very uncertain whether IVF changes OHSS rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 6.86 [0.35, 134.59]
  1 study · 207 participants
  Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 0.31 [0.03, 3.04]
  1 study · 207 participants
  Very low

IVF vs expectant management

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with expectant management (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 3.24 [1.07, 9.8]
  2 studies · 86 participants
  Very low

IVF vs expectant management

The review found no eligible studies for this question.

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IVF vs expectant management

The review found no eligible studies for this question.

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IVF vs expectant management

The review found no eligible studies for this question.

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IVF vs unstimulated IUI

IVF may leads to higher live birth rate per woman randomised compared with unstimulated IUI (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 2.47 [1.19, 5.12]
  2 studies · 156 participants
  Low

IVF vs unstimulated IUI

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 4.83 [0.94, 24.95]
  1 study · 43 participants
  Very low

IVF vs unstimulated IUI

It is very uncertain whether IVF changes multiple pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.03 [0.04, 27.29]
  1 study · 43 participants
  Very low

IVF vs unstimulated IUI

The review found no eligible studies for this question.

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IVF vs IUI

IVF showed no clear difference in live birth rate per couple (all cycles) compared with IUI (low certainty).

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  OR 0.77 [0.25, 2.35]
  Studies not reported
  Low
• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  OR 1.03 [0.43, 2.45]
  Studies not reported
  Very low

IVF vs IUI

The review found no eligible studies for this question.

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IVF vs IUI

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

IVF vs IUI

It is very uncertain whether IVF changes pregnancy rate per couple (all cycles) compared with IUI (very low certainty).

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  OR 1.27 [0.33, 4.97]
  Studies not reported
  Very low

Natural cycle IVF vs standard IVF

Natural cycle IVF showed no clear difference in live birth per woman compared with standard IVF (moderate certainty).

• Natural cycle in vitro fertilisation (IVF) for subfertile couples 2013 · Cochrane Headline outcomes only
  OR 0.68 [0.46, 1.01]
  2 studies · 425 participants
  Moderate