Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

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578 questions · 600 findings · 55 reviews · Headline outcomes only

No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 100 · 16.7%Low 142 · 23.7%Moderate 116 · 19.3%High 30 · 5%

Intermittent vs any daily iron supplementation

Iron deficiency (using ferritin concentrations) · children under 12 years of age

It is very uncertain whether intermittent changes iron deficiency (using ferritin concentrations) compared with daily use of iron supplements (very low certainty).

1 finding from 1 review

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review