Findings

What do systematic reviews say?

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1,793 questions · 1,866 findings · 339 reviews

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No studies found 245 · 13.1%GRADE not reported 142 · 7.6%Very low 612 · 32.8%Low 513 · 27.5%Moderate 305 · 16.3%High 49 · 2.6%

Acupuncture vs NSAIDs

Function (short‐term) Harris function score from: 0 to 47 (higher is better function). · patients with hip osteoarthritis

1 finding from 1 review

Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

Pain (short term) WOMAC scale from 0 to 20 points (higher is worse pain). · patients with hip osteoarthritis

1 finding from 1 review

Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
Low

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

Function (short‐term) WOMAC scale from: 0 to 100 (higher is worse function). · patients with hip osteoarthritis

1 finding from 1 review

Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
Low

Ball (stud) attachment system vs Telescopic attachment system

Prosthodontic maintenance: reline of implant overdenture (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)

It is very uncertain whether ball (stud) attachment system changes prosthodontic maintenance: reline of implant overdenture (short term) compared with telescopic attachment system (very low certainty).

1 finding from 1 review

Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws 2018 · Cochrane All outcomes
Short term (1 to 3 years)
RR 2.33 [0.81, 6.76]
1 study · 22 participants
Very low

Ball (stud) attachment system vs Telescopic attachment system

Prosthodontic maintenance: matrix replaced (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)

It is very uncertain whether ball (stud) attachment system changes prosthodontic maintenance: matrix replaced (short term) compared with telescopic attachment system (very low certainty).

1 finding from 1 review

Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws 2018 · Cochrane All outcomes
Short term (1 to 3 years)
RR 1.75 [0.71, 4.31]
1 study · 22 participants
Very low

EMP + CAF vs CAF

Attachment change · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm)

EMP + CAF led to higher clinical attachment level change (short and medium term) compared with CAF; GRADE not reported.

1 finding from 1 review

Root coverage procedures for treating localised and multiple recession‐type defects 2018 · Cochrane All outcomes
Short and medium term (6 to 24 months)
MD 0.35 [0.09, 0.61]
3 studies
GRADE not reported

Intervention not reported

Quality of life: general ‐ average endpoint score (GWB, high score = good) ‐ short term ( · People with schizophrenia and schizophrenia‐like disorders

1 finding from 1 review

Music therapy for people with schizophrenia and schizophrenia‐like disorders 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 72 participants
Moderate

Imiquimod vs vehicle

Short‐term clinical cure (up to 3 months after start of treatment) (completely cleared short term) · molluscum contagiosum

Imiquimod showed no clear difference in short‐term clinical cure (up to 3 months after start of treatment)… compared with vehicle (moderate certainty).

1 finding from 1 review

Interventions for cutaneous molluscum contagiosum 2017 · Cochrane Headline outcomes only
RR 1.33 [0.92, 1.93]
4 studies · 850 participants
Moderate

Imiquimod vs vehicle

Short‐term clinical improvement (up to 3 months after start of treatment) · molluscum contagiosum

Imiquimod showed no clear difference in short‐term clinical improvement (up to 3 months after start of… compared with vehicle (high certainty).

1 finding from 1 review

Interventions for cutaneous molluscum contagiosum 2017 · Cochrane Headline outcomes only
RR 1.14 [0.89, 1.47]
4 studies · 850 participants
High

Emergency endovascular aneurysm repair vs conventional open repair

Short‐term mortality (30‐day or in‐hospital) · people diagnosed with RAAA

Emergency endovascular aneurysm repair showed no clear difference in short‐term mortality (30‐day or in‐hospital) compared with conventional open repair (moderate certainty).

1 finding from 1 review

Endovascular treatment for ruptured abdominal aortic aneurysm 2017 · Cochrane Headline outcomes only
OR 0.88 [0.66, 1.16]
4 studies · 868 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Death ‐ in all participants ‐ short term · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in death ‐ in all participants ‐ short term compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.21 [0.57, 2.56]
1 study · 503 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in all participants ‐ short term Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in all participants ‐ short term Composite… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
OR 0.83 [0.32, 2.15]
1 study · 477 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Neurological sequelae ‐ in all participants‐ short term Clinical assessment11 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in neurological sequelae ‐ in all participants‐ short term Clinical… compared with long‐acting (oily) chloramphenicol (low certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
RR 1.29 [0.63, 2.62]
1 study · 477 participants
Low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Adverse events ‐ short term · people suspected to have meningococcal disease (adults and children)

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
GRADE not reported

Zuclopenthixol dihydrochloride vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Leaving the study early · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes leaving the study early (any reason, short and medium term) compared with perphenazine (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride for schizophrenia 2017 · Cochrane Headline outcomes only
RR 0.63 [0.27, 1.47]
2 studies · 104 participants
Very low

Zuclopenthixol dihydrochloride vs RISPERIDONE

Adverse effects: Clinically important general adverse effect ‐ short term (EPSEs requiring medication) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect ‐ short… compared with risperidone (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride for schizophrenia 2017 · Cochrane Headline outcomes only
RR 1.92 [1.12, 3.28]
1 study · 98 participants
Very low

Zuclopenthixol dihydrochloride vs RISPERIDONE

Leaving the study early · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes leaving the study early (any reason, short and medium term) compared with risperidone (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride for schizophrenia 2017 · Cochrane Headline outcomes only
RR 1.3 [0.84, 2.02]
3 studies · 154 participants
Very low

Intervention not reported

Health‐related quality of life Short Form 12 Health Survey (SF‐12) · people with ALS/MND

1 finding from 1 review

Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 128 participants
Moderate

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Clinical response: mean score/change in global state: mean CGI score (high = poor) Short term (8 weeks) · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Very low

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Global state: Response ‐ proxy outcome ‐ mental state: 1. General ‐ average score (Brief Psychiatric Rating Scale by over 24 weeks · people with treatment‐resistant schizophrenia

1 finding from 1 review

Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low