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Evidence found and GRADE certainty

41 questions · 49 findings · 6 reviews

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No studies found 8 · 16.3%GRADE not reported 16 · 32.7%Very low 6 · 12.2%Low 4 · 8.2%Moderate 5 · 10.2%High 10 · 20.4%

Hyperbaric oxygen vs control without HBOT

Complete resolution or significant improvement of osteoradionecrosis · any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw

Hyperbaric oxygen therapy (HBOT) showed no clear difference in complete resolution or significant improvement of osteoradionecrosis compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Healing of MRONJ · People with established (manifest) MRONJ

It is very uncertain whether hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy changes healing of MRONJ compared with conventional therapy (very low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review