Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 1 · 14.3%

Higher vs lower amino acid intake

Retinopathy of prematurity · preterm infants

It is very uncertain whether higher changes retinopathy of prematurity compared with lower amino acid intake (very low certainty).

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
RR 0.44 [0.21, 0.93]
4 studies · 269 participants
Very low

Higher vs lower amino acid intake

Mortality before hospital discharge · preterm infants

Higher showed no clear difference in mortality to hospital discharge compared with lower amino acid intake (low certainty).

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
RR 0.9 [0.69, 1.17]
14 studies · 1407 participants
Low

Higher vs lower amino acid intake

Neurodevelopmental disability · preterm infants

It is very uncertain whether higher changes neurodevelopmental disability compared with lower amino acid intake (very low certainty).

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
RR 1.04 [0.48, 2.23]
2 studies · 201 participants
Very low

Higher vs lower amino acid intake

Postnatal growth failure (weight < 10th percentile) · preterm infants

It is very uncertain whether higher changes postnatal growth failure at discharge (weight < 10th centile) compared with lower amino acid intake (very low certainty).

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
RR 0.74 [0.56, 0.97]
3 studies · 203 participants
Very low

Higher vs lower amino acid intake

Weight gain · preterm infants

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 291 participants
Very low

Higher vs lower amino acid intake

Head circumference gain (mm/week) · preterm infants

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 315 participants
Very low

Higher vs lower amino acid intake

Abnormal blood urea nitrogen (various criteria) · preterm infants

Higher leads to higher abnormal blood urea nitrogen (various criteria) compared with lower amino acid intake (high certainty).

1 finding from 1 review

Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
RR 2.77 [2.13, 3.61]
7 studies · 688 participants
High