Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 714 findings · 96 reviews

No studies found 98 · 13.7%GRADE not reported 191 · 26.8%Very low 157 · 22%Low 161 · 22.5%Moderate 87 · 12.2%High 20 · 2.8%

HFNC vs low flow nasal cannula (LFNC)

Treatment failure · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

Summary of findings table ‐ High flow nasal cannula (HFNC) may leads to lower treatment failure compared with low flow nasal cannula (LFNC) (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with nasal intermittent positive pressure ventilation (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in treatment failure within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Nasal trauma (during assigned treatment) · preterm infants requiring primary respiratory support

Nasal high flow probably leads to lower nasal trauma (during assigned treatment) compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review