What do systematic reviews say?

High‐dose vs low‐dose colchicine

• Colchicine for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 126 participants
  GRADE not reported

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

The review found no eligible studies for this question.

• Role of chemotherapy additional to high‐dose methotrexate for primary central nervous system lymphoma (PCNSL) 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐dose colchicine vs placebo

• Colchicine for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  GRADE not reported

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

• Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
  RR 8.02 [1.03, 62.37]
  2 studies · 77 participants
  Moderate

Summary of findings table ‐ High‐dose dexamethasone (12 mg or higher) vs low‐dose dexamethasone (6 mg to 8 mg)

• Systemic corticosteroids for the treatment of COVID‐19: Equity‐related analyses and update on evidence 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1080 participants
  Very low