Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 1 · 16.7%Very low 0 · 0%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%

HALOPERIDOL + PROMETHAZINE vs haloperidol

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion by 12 hours compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (low certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.83 [0.28, 2.44]
1 study · 60 participants
Low

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE led to lower global state: Needing restraints or seclusion ‐ by 12 hours compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM; GRADE not reported.

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.24 [0.1, 0.55]
1 study · 60 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs ZIPRASIDONE

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion ‐ by 12 hours compared with ANTIPSYCHOTIC ‐ ZIPRASIDONE (moderate certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.5 [0.19, 1.29]
1 study · 60 participants
Moderate

HALOPERIDOL + PROMETHAZINE vs lorazepam

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion ‐ by 12 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (moderate certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.82 [0.35, 1.89]
1 study · 200 participants
Moderate

HALOPERIDOL + PROMETHAZINE vs midazolam

Global outcome ‐ need for restraint or seclusion · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion‐ by 2 hours compared with BENZODIAZEPINES ‐ MIDAZOLAM (moderate certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 1.22 [0.82, 1.82]
1 study · 301 participants
Moderate

HALOPERIDOL + PROMETHAZINE vs OLANZAPINE

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion by 12 hours compared with ANTIPSYCHOTIC ‐ OLANZAPINE (low certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 5 [0.62, 40.28]
1 study · 60 participants
Low