Findings

What do systematic reviews say?

263 questions · 270 findings · 9 reviews

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No studies found 85 · 31.5%GRADE not reported 24 · 8.9%Very low 85 · 31.5%Low 42 · 15.6%Moderate 21 · 7.8%High 13 · 4.8%

HALOPERIDOL vs placebo

Relapse · patients with schizophrenia

It is very uncertain whether HALOPERIDOL changes relapse compared with PLACEBO (very low certainty).

1 finding from 1 review

Haloperidol versus placebo for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.69 [0.55, 0.86]
2 studies · 70 participants
Very low

HALOPERIDOL vs placebo

Leaving the study early · patients with schizophrenia

HALOPERIDOL showed no clear difference in leaving the study early compared with PLACEBO (moderate certainty).

1 finding from 1 review

Haloperidol versus placebo for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.54 [0.29, 1]
8 studies · 304 participants
Moderate

HALOPERIDOL vs placebo

Satisfaction with treatment · patients with schizophrenia

1 finding from 1 review

Haloperidol versus placebo for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL vs placebo

Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia

HALOPERIDOL probably leads to higher adverse effects: Movement disorders ‐ parkinsonism compared with PLACEBO (moderate certainty).

1 finding from 1 review

Haloperidol versus placebo for schizophrenia 2013 · Cochrane Headline outcomes only
RR 5.48 [2.68, 11.22]
5 studies · 485 participants
Moderate

HALOPERIDOL vs placebo

The event rate of intensive care delirium within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 1.01 [0.87, 1.17]
1 study · 1439 participants
Moderate

HALOPERIDOL vs placebo

In‐hospital mortality within 28 days. · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
RR 0.98 [0.8, 1.22]
2 studies · 1580 participants
Moderate

Number of delirium ‐ and coma‐free days (within 28 days) measured by CAM‐ICU or ICDSC · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
Moderate

HALOPERIDOL vs placebo

Ventilator‐free days up to day 28 · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1439 participants
High

HALOPERIDOL vs placebo

Duration of ICU stay · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
High

HALOPERIDOL vs placebo

Cognitive impairment · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HALOPERIDOL vs placebo

Adverse events · critically ill patients 18 years or older demanding mechanical ventilation within the first 72 hours (Page 2013) or anticipated needing…

1 finding from 1 review

Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1580 participants
Moderate

HALOPERIDOL + PROMETHAZINE vs haloperidol

Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE leads to lower tranquil or asleep: Not tranquil or asleep ‐ by 30 minutes compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (high certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.65 [0.49, 0.87]
1 study · 316 participants
High

HALOPERIDOL + PROMETHAZINE vs haloperidol

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion by 12 hours compared with ANTIPSYCHOTIC ‐ HALOPERIDOL (low certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.83 [0.28, 2.44]
1 study · 60 participants
Low

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE led to lower global state: Needing restraints or seclusion ‐ by 12 hours compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM; GRADE not reported.

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.24 [0.1, 0.55]
1 study · 60 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE may leads to lower adverse effects: Specific and serious adverse effect ‐ by 24 hours… compared with ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM (low certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.12 [0.03, 0.49]
2 studies · 117 participants
Low

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Service outcomes: Not discharged ‐ by 2 weeks · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Aggression · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Economic outcomes: Cost of care · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported