Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 1 · 33.3%High 1 · 33.3%

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Global outcomes · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in global outcomes compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 1.21 [0.84, 1.76]
1 study · 316 participants
Moderate

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

Global outcomes ‐ overall improvement · people with long‐term aggression in psychosis

HALOPERIDOL leads to lower global outcomes ‐ overall improvement compared with OTHER ANTIPSYCHOTICS (high certainty).

1 finding from 1 review

Haloperidol for long‐term aggression in psychosis 2016 · Cochrane Headline outcomes only
no estimate extracted
83 participants
High

HALOPERIDOL vs ARIPIPRAZOLE

Global outcome ‐ need for benzodiazepine during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 1.26 [0.74, 2.16]
2 studies · 477 participants
Very low