Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 25 findings · 2 reviews

No studies found 3 · 12%GRADE not reported 0 · 0%Very low 14 · 56%Low 5 · 20%Moderate 2 · 8%High 1 · 4%

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: h. THIOTHIXENE

Global outcome No improvement at 1 hour · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome No improvement at 1 hour compared with OTHER ANTIPSYCHOTIC: i. THIOTHIXENE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Global outcome ‐ need for benzodiazepine during 24 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in global outcome ‐ need for benzodiazepine compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no improvement compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Global outcome ‐ rated as severe ‐ CGI‐S · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome ‐ rated as severe ‐ CGI‐S compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Global outcome ‐ need for benzodiazepine during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review