What do systematic reviews say?

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Guidewire‐assisted cannulation probably leads to lower post‐ERCP pancreatitis (PEP) compared with contrast‐assisted cannulation (moderate certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 0.51 [0.36, 0.72]
  15 studies · 4426 participants
  Moderate

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Guidewire‐assisted cannulation may leads to higher primary cannulation success compared with contrast‐assisted cannulation (low certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 1.06 [1.01, 1.12]
  13 studies · 3962 participants
  Low

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Guidewire‐assisted cannulation showed no clear difference in overall cannulation success compared with contrast‐assisted cannulation (moderate certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 1.01 [1, 1.03]
  15 studies · 4426 participants
  Moderate

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Guidewire‐assisted cannulation probably leads to lower need for precut sphincterotomy compared with contrast‐assisted cannulation (moderate certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 0.79 [0.64, 0.96]
  10 studies · 2849 participants
  Moderate

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Guidewire‐assisted cannulation showed no clear difference in post‐sphincterotomy bleeding compared with contrast‐assisted cannulation (low certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 0.87 [0.49, 1.54]
  7 studies · 2122 participants
  Low

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

It is very uncertain whether guidewire‐assisted cannulation changes perforation compared with contrast‐assisted cannulation (very low certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 0.93 [0.11, 8.23]
  8 studies · 2522 participants
  Very low

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 2276 participants
  Moderate