What do systematic reviews say?

GnRHa treatment vs placebo or no pretreatment

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 858 participants
  Low

GnRHa treatment vs placebo or no pretreatment

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 443 participants
  Very low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 617 participants
  Low

GnRHa treatment vs placebo or no pretreatment

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 549 participants
  Very low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 258 participants
  Very low

GnRHa treatment vs placebo or no pretreatment

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 0.85 [0.26, 2.75]
  4 studies · 121 participants
  Low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 0.54 [0.29, 1.01]
  6 studies · 601 participants
  Moderate

GnRHa treatment vs placebo or no pretreatment

GnRHa treatment showed no clear difference in postoperative morbidity compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 1.07 [0.43, 2.64]
  5 studies · 190 participants
  Low
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 0.54 [0.32, 0.91]
  7 studies · 772 participants
  Low

GnRHa treatment vs placebo or no pretreatment

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 427 participants
  Low

GnRHa treatment vs placebo or no pretreatment

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 834 participants
  Low

GnRHa treatment vs placebo or no pretreatment

The review found no eligible studies for this question.

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRHa treatment vs placebo or no pretreatment

GnRHa treatment probably leads to higher adverse events compared with placebo or no pretreatment (preoperative outcomes) (moderate certainty).

• Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
  OR 2.78 [1.77, 4.36]
  4 studies · 755 participants
  Moderate