What do systematic reviews say?

Glyceryl trinitrate (GTN) vs no GTN

Glyceryl trinitrate (GTN) leads to higher adverse event: Headache, on treatment (7‐12 days) compared with no GTN (high certainty).

• Nitric oxide donors (nitrates), L‐arginine, or nitric oxide synthase inhibitors for acute stroke 2017 · Cochrane Headline outcomes only
  OR 2.37 [1.55, 3.62]
  5 studies · 4186 participants
  High