Findings

What do systematic reviews say?

23 questions · 42 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 42 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.014 [0.857, 1.199]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.016 [0.867, 1.191]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.005 [0.940, 1.074]
483725 participants
GRADE not reported

Genetically predicted periodontitis vs Without periodontitis (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037).

1 finding from 1 review

The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study. 2025 All outcomes
Genetic epidemiology (European-ancestry GWAS summary data)
OR 1.24 [1.03, 1.49]
Studies not reported
GRADE not reported