Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).
2 findings from 1 review
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomesLifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitisOR 1.422 [1.027, 1.969]281786 participantsGRADE not reported
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomesLifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effectOR 1.343 [0.948, 1.901]281786 participantsGRADE not reported