Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)
Osteoporosis with pathological fracture · European-ancestry adults
In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).
2 findings from 1 review
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomesLifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitisOR 1.279 [0.955, 1.713]376746 participantsGRADE not reported
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomesLifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effectOR 1.261 [0.918, 1.732]376746 participantsGRADE not reported