Findings

What do systematic reviews say?

3 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Osteoporosis · European-ancestry adults

In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitis
OR 1.165 [1.020, 1.331]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.156 [0.994, 1.343]
483725 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Osteoporosis with pathological fracture · European-ancestry adults

In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitis
OR 1.279 [0.955, 1.713]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.261 [0.918, 1.732]
376746 participants
GRADE not reported

Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS)

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for periodontitis
OR 1.422 [1.027, 1.969]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.343 [0.948, 1.901]
281786 participants
GRADE not reported