What do systematic reviews say?

Participant‐reported pain relief of 50% or greater · adults with postherpetic neuralgia

Withdrawals due to adverse events · adults with neuropathic pain

Serious adverse events · adults with neuropathic pain

Death · adults with neuropathic pain

IMMPACT definition ‐ any substantial pain benefit · adults with postherpetic neuralgia

Patient Global Impression of Change much or very much improved · adults with postherpetic neuralgia

IMMPACT definition ‐ any at least moderate pain benefit · adults with postherpetic neuralgia

Participant‐reported pain relief of 50% or greater · people with diabetic peripheral neuropathy

'Substantial benefit' (≥ 50% reduction in pain or PGIC very much improved) · people with diabetic peripheral neuropathy

Patient Global Impression of Change much or very much improved · people with diabetic peripheral neuropathy

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · people with diabetic peripheral neuropathy

Proportion of participants experiencing adverse events · adults with neuropathic pain

At least 30% reduction in pain · adults with fibromyalgia

At least 50% reduction in pain · adults with fibromyalgia

PGIC ‐ any category of "better" at 12 weeks · adults with fibromyalgia

Withdrawals due to adverse events · adults with fibromyalgia

Serious adverse events · adults with fibromyalgia

Deaths · adults with fibromyalgia