What do systematic reviews say?

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  Adverse-effect data scarcely reported: a stain score in one trial and 'any side effects' in one trial without complete or useable data (stated 'no side effects observed in both groups'). No useful information on tooth…
  Studies not reported
  GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

The review found no eligible studies for this question.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  Fluorosis data have not been reported in any of the trials.
  0 studies
  No studies found

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Fluoride mouthrinse, gel or varnish combined with fluoride… showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 1.06 [0.93, 1.22]
  5 studies · 1998 participants
  GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.10 [0.02, 0.17]
  9 studies · 4026 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride varnish

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride varnish alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 0.75 [0.22, 2.59]
  1 study · 196 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 1.29 [0.61, 2.71]
  2 studies · 294 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride varnish

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.19
  1 study · 186 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.48 [0.12, 0.84]
  1 study · 71 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.15
  1 study · 173 participants
  GRADE not reported