What do systematic reviews say?

Enteral nutrition vs no intervention

Enteral nutrition may leads to lower all‐cause mortality compared with no intervention (low certainty).

• Enteral nutrition formulations for acute pancreatitis 2015 · Cochrane Headline outcomes only
  RR 0.5 [0.29, 0.86]
  4 studies · 511 participants
  Low

Late parenteral nutrition vs early parenteral nutrition

Late parenteral nutrition may leads to lower in‐hospital all‐cause mortality compared with early parenteral nutrition (low certainty).

• Early versus late parenteral nutrition for critically ill term and late preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.35 [0.14, 0.87]
  1 study · 209 participants
  Low

Semi‐elemental enteral nutrition vs control

• Enteral nutrition formulations for acute pancreatitis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 35 participants
  Very low

Fibre‐enriched enteral nutrition vs control

It is very uncertain whether fibre‐enriched enteral nutrition changes all‐cause mortality compared with control (very low certainty).

• Enteral nutrition formulations for acute pancreatitis 2015 · Cochrane Headline outcomes only
  RR 0.23 [0.03, 1.84]
  2 studies · 103 participants
  Very low

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes all‐cause mortality compared with placebo (very low certainty).

• Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.58 [0.3, 1.13]
  2 studies · 671 participants
  Very low

Enteral zinc supplementation vs no zinc supplementation

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

• Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates 2021 · Cochrane Headline outcomes only
  RR 0.55 [0.31, 0.97]
  3 studies · 345 participants
  Low

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Inositol supplementation IV initially followed by enteral… showed no clear difference in all‐cause mortality (outcome collected through first event: death,… compared with placebo (moderate certainty).

• Inositol in preterm infants at risk for or having respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  RR 1.35 [0.91, 2]
  2 studies · 701 participants
  Moderate